Even the best in silico models will be limited by the data and methodology used to build them, so an in-depth understanding of results is extremely important for those tasked with expert review. I’ll also show some worked examples of results from the new system.Įxpert Review: here are your “raw materials”…ĭerek Nexus (an expert tool) and Sarah Nexus (a statistical tool) are Lhasa’s solution for ICH M7 hazard assessments. In this post we discuss how consideration of the user’s journey led to Lhasa tackling the ICH M7 use case with a brand-new automated workflow, now available to Derek and Sarah users in Nexus 2.3. In his blog “Human review of in silico predictions of toxicity”, Principal Scientist, Alex Cayley, outlined the reasons why expert review is essential when using in silico tools to assess toxicity, particularly in the ICH M7 use case where expert review of two complementary in silico systems is required.
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